From the moment the Doctor (David Tennant) walks into the life of medical student Martha Jones (Freema Agyeman) he changes it forever. Together they find themselves travelling through time and space encountering extraordinary events, amazing worlds and faces both old and new.
In Elizabethan London, they meet William Shakespeare at the Globe Theatre where witch-like creatures are plotting to create a Carrionite empire on Earth. In the year Five Billion and Fifty Three, Mankind and Catkind are caught in a terrible trap while back in present day London 76 year old Professor Lazarus recaptures his youth with consequences that threaten Martha's entire family.
Martha and the Doctor's journey also brings them face to face with the ruthless Judoon, a vicious plasmavore and the Doctor's sworn enemies, the Daleks, who have been hiding in1930s New York with a terrifying plan for humanity.