After his explosive regeneration, the Eleventh Doctor awakes to discover his TARDIS is about to crash! After falling from the sky, he pulls himself out of the wreckage to come face-to-face with young Amy Pond.
Still wearing the remains of the Tenth Doctor's suit, ripped and raggedy from the damage after the TARDIS control room exploded, the Doctor promises to take Amy to the stars. But before they can begin their journey, they become embroiled in an alien plot that could destroy the Earth!
Later the Doctor makes good his promise, and Amy boards the regenerated TARDIS, ready to take to the stars on a series of wild adventures that will change her life. Amy and the Doctor explore time and space, visiting 16th century Venice, France during the 1890s and the United Kingdom in the far future, now an entire nation floating in space.
As always, wherever the Doctor goes, his oldest enemies are never far behind ? the Daleks are hatching a new master plan from the heart of war-torn London in the 1940s. But they are not the only strange creatures the Doctor and Amy must face ? there are also alien vampires, humanoid reptiles, old enemies such as the Weeping Angels, and a silent menace that follows Amy and the Doctor around wherever they go.