In the wake of Monroe and Rosalee's wedding, things have never been more chaotic. Nick, having lost his Grimm abilities, must dig deep and decide what type of person he wants to be, while Juliette continues to try to come to grips with Nick's recent "betrayal." Monroe and Rosalee find themselves having to put their honeymoon plans on hold to try to not only figure out what happened to Nick, but also how to reverse it.
With Captain Renard in critical condition after being shot by Agent Steward, Sergeant Wu's biggest fears are becoming reality thanks to recent events, not the least of which is the strange young woman seen with Nick and the sketches he saw in one of her books.
In Europe, Viktor is trying to make the best of the Royals' mishandling of the "hexenbaby," using Adalind's desperation and vulnerability to make her his prisoner.
On top of all this, Wesen crime in Portland doesn't seem to be letting up at all, with even more dangerous Wesen making their way to the great northwest. It's going to take all of Team Grimm's strength and energy to keep Portland from bursting open at the seams.